A Near-IR Fluorescent Dasatinib Derivative That Localizes in Cancer Cells
نویسندگان
چکیده
منابع مشابه
Engineering of near IR fluorescent albumin nanoparticles for in vivo detection of colon cancer
BACKGROUND The use of near-infrared (NIR) fluorescence imaging techniques has gained great interest for early detection of cancer because water and other intrinsic biomolecules display negligible absorption or autofluorescence in this region. Novel fluorescent nanoparticles with potential to improve neoplasm detection sensitivity may prove to be a valuable tool in early detection of colon tumor...
متن کاملNear - IR Fluorescent Molecular Hydrogen Emission from NGC 2023
Spectra from 1 to 2 ·5 μm, at 230–430 spectral resolution, are presented of the fluorescent molecular hydrogen line emission from two locations in the reflection nebula NGC 2023. Over 100 H2 lines can be identified in the spectra, although blending and poor atmospheric transmission mean that reliable level column densities can only be obtained from 35 lines. This latter group includes lines fro...
متن کاملSquaraine-derived rotaxanes: highly stable, fluorescent near-IR dyes.
Squaraines are fluorescent, near-IR dyes with promising photophysical properties for biomedical applications. A limitation with these dyes is their inherent reactivity with nucleophiles, which leads to loss of the chromophore. Another drawback is their tendency to form nonfluorescent aggregates in water. Both problems can be greatly attenuated by encapsulating the dye inside an amide-containing...
متن کاملSquaraine-derived rotaxanes: sterically protected fluorescent near-IR dyes.
A squaraine dye with bulky end groups is employed as the thread component in two Leigh-type amide rotaxanes. The rotaxanes are synthesized in a simple two-step process. X-ray crystal structures of the rotaxanes show that the pyridyl-containing macrocycle is more rigid and wraps more tightly around the cyclobutene core of the squaraine thread compared to the isophthalamide-containing macrocycle....
متن کاملA Combined Mid-IR/Near-IR Spectrometer
When analysts are faced with the decision of selecting either mid-IR (MIR) or near-IR (NIR) spectroscopy for materials characterization, the decision is usually based on the analytical, sampling, and/ or operational needs. For example, when the greatest analytical specificity is required or certain inorganic materials need to be measured, the choice favors MIR; whereas the need to keep an unsta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2019
ISSN: 1043-1802,1520-4812
DOI: 10.1021/acs.bioconjchem.9b00118